To ensure you have protection for VDI machines at first boot, follow these recommendations: When non-persistent VDI machines are onboarded to Microsoft Defender ATP at first boot, you also want to provide Microsoft Defender AV protection for non-persistent VDI machines at first boot. In my first VDI post I described how the non-persistent VDI deployment type works and interacts in a VDI master/child relationship. This article covers optimizations, best practices, and recommended settings for configuring Microsoft Defender AV in a non-persistent VDI environment. this article includes guidance and recommendations for Microsoft Defender Antivirus on non-persistent VDI machines. Microsoft Defender Antivirus is a critical and built-in component in the Microsoft endpoint protection platform.

Among all other settings, it's crucial to ensure antivirus protection on the device is configured optimally.

Antivirus can also benefit from VDI specific configurations and tuning.

The delicate balance of performance and usability are key to the user experience and can require fine tuning of all sorts of items in Windows. Virtual Desktop Infrastructure (VDI) brings an interesting dynamic when tuning the platform.

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